⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670548 | 0.75 | NOS3 (0.31) | — | |
| SCHEMBL10937495 | 0.71 | NOS1 (0.36) | — | |
| SCHEMBL6694407 | 0.58 | CYP19A1 (0.61) | — | |
| SCHEMBL3265923 | 0.58 | NOS1 (0.31) | — | |
| SCHEMBL10806119 | 0.58 | — | — | |
| SCHEMBL2227801 | 0.58 | — | — | |
| SCHEMBL6795142 | 0.58 | TRIM24 (0.30) | — | |
| SCHEMBL3271573 | 0.57 | — | — | |
| SCHEMBL11886902 | 0.57 | — | — | |
| SCHEMBL3267280 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200406-A1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001005765-A1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA (IT) | 2001-01-25 | — | — | WO | disclosed |