Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508671 | 0.93 | PTGS2 (0.45) | PTGS2PTGS1PPARDTEKRXRA | |
| SCHEMBL7505602 | 0.92 | CA2 (0.42) | PTGS2PTGS1PPARDRXRARXRB | |
| SCHEMBL7510121 | 0.90 | PTGS2 (0.46) | PTGS2PTGS1PPARDRXRARXRB | |
| SCHEMBL7504843 | 0.89 | PTGS2 (0.45) | PTGS2PTGS1 | |
| SCHEMBL7503574 | 0.88 | PTGS2 (0.46) | PTGS2PTGS1RXRARXRBNR4A2 | |
| SCHEMBL7506251 | 0.88 | PTGS2 (0.46) | PTGS2PTGS1PPARDRXRARXRB | |
| SCHEMBL7507741 | 0.87 | PTGS2 (0.47) | PTGS2PTGS1RXRARXRBNR4A2 | |
| SCHEMBL7501042 | 0.86 | PTGS2 (0.55) | PTGS2PTGS1PPARDRXRARXRB | |
| SCHEMBL7498353 | 0.86 | PTGS2 (0.55) | PTGS2PTGS1PPARDRXRARXRB | |
| SCHEMBL7508070 | 0.85 | PTGS2 (0.43) | PTGS2PTGS1RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-B1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6090834-A | ANALGESICS; RHEUMATIC DISORDERS; SKIN DISORDERS; GASTROINTESTINAL DISORDERS | G.D. SEARLE & CO. (US) | 2000-07-18 | — | — | US | disclosed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | disclosed |