Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7514688 | 0.94 | ALOX15 (0.45) | CNR1ALOX15MDM2TSHR | |
| SCHEMBL7506995 | 0.90 | ALOX15 (0.45) | CNR1ALOX15MDM2TSHR | |
| SCHEMBL7502916 | 0.89 | CNR1 (0.41) | CNR1 | |
| SCHEMBL7506988 | 0.89 | CNR1 (0.41) | CNR1 | |
| SCHEMBL7505691 | 0.87 | ALOX15 (0.44) | CNR1ALOX15MDM2 | |
| SCHEMBL7514736 | 0.85 | ALOX15 (0.48) | CNR1ALOX15TSHR | |
| SCHEMBL7508929 | 0.84 | ALOX15 (0.49) | CNR1ALOX15TSHR | |
| SCHEMBL7506263 | 0.84 | ALOX15 (0.49) | CNR1ALOX15TSHR | |
| SCHEMBL7501257 | 0.84 | ALOX15 (0.49) | CNR1ALOX15TSHR | |
| SCHEMBL7506242 | 0.84 | ALOX15 (0.49) | CNR1ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |