Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7508726 | 0.90 | DGAT1 (0.36) | DGAT1CCNCCDK8 | |
| SCHEMBL30531839 | 0.83 | DGAT1 (0.37) | DGAT1CCNCCDK8NPC1ALOX5AP | |
| SCHEMBL25249478 | 0.82 | DGAT1 (0.42) | DGAT1CCNCCDK8ALOX5APFEN1 | |
| SCHEMBL29392834 | 0.80 | DGAT1 (0.45) | DGAT1CCNCCDK8ALOX5APFEN1 | |
| SCHEMBL25289208 | 0.80 | DGAT1 (0.45) | DGAT1CCNCCDK8ALOX5APFEN1 | |
| SCHEMBL29395303 | 0.80 | DGAT1 (0.42) | DGAT1NPC1 | |
| SCHEMBL25242533 | 0.79 | DGAT1 (0.36) | DGAT1CCNCCDK8 | |
| SCHEMBL25284186 | 0.79 | DGAT1 (0.41) | DGAT1CCNCCDK8ALOX5APFEN1 | |
| SCHEMBL25239322 | 0.79 | DGAT1 (0.41) | DGAT1CCNCCDK8ALOX5APFEN1 | |
| SCHEMBL29394926 | 0.79 | DGAT1 (0.41) | DGAT1CCNCCDK8ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042320-B1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | ASTRAZENECA UK LTD (GB) | 2002-02-13 | — | — | EP | disclosed |
| US-6218376-B1 | FOR TREATING INFLAMMATORY DISEASES | ASTRAZENECA UK LIMITED (GB) | 2001-04-17 | — | — | US | disclosed |
| EP-1042320-A1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | AstraZeneca UK Limited (GB) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999026944-A1 | NEW COMPOUNDS WHICH ARE P2-PURINOCEPTOR 7-TRANSMEMBRANE (TM) G-PROTEIN COUPLED RECEPTOR ANTAGONISTS | ASTRAZENEKA UK LIMITED (GB) | 1999-06-03 | — | — | WO | disclosed |