Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.65 |
| ▸ | MET | P08581 | 1/20 | 0.65 |
| ▸ | PIM1 | P11309 | 1/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.65 |
| ▸ | PRKACA | P17612 | 1/20 | 0.65 |
| ▸ | GRK5 | P34947 | 1/20 | 0.65 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.65 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.65 |
| ▸ | CDK8 | P49336 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | CDK7 | P50613 | 1/20 | 0.65 |
| ▸ | CDK9 | P50750 | 1/20 | 0.65 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.65 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.65 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7676525 | 0.90 | CHEK1 (0.62) | CHEK1AURKANTRK1METPIM1 | |
| SCHEMBL7679568 | 0.88 | CHEK1 (0.60) | CHEK1AURKANTRK1METPIM1 | |
| SCHEMBL7673400 | 0.86 | MMP2 (0.67) | CHEK1AURKANTRK1METPIM1 | |
| SCHEMBL7676192 | 0.84 | MMP9 (0.87) | MMP9MMP2MMP1 | |
| SCHEMBL7670905 | 0.84 | CHEK1 (0.66) | CHEK1AURKANTRK1METPIM1 | |
| SCHEMBL7673781 | 0.83 | MMP9 (0.57) | CHEK1AURKANTRK1METPIM1 | |
| SCHEMBL7673930 | 0.83 | MMP2 (0.57) | CHEK1AURKANTRK1METPIM1 | |
| SCHEMBL7451229 | 0.81 | CHEK1 (0.57) | CHEK1AURKANTRK1METPIM1 | |
| SCHEMBL7506195 | 0.81 | CHEK1 (0.57) | CHEK1AURKANTRK1METPIM1 | |
| SCHEMBL7670885 | 0.80 | MMP9 (0.63) | CHEK1AURKANTRK1METPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001930-B1 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2002-12-04 | — | — | EP | disclosed |