SCHEMBL7510364

SCHEMBL7510364

COc1cc(C(=O)N(N)C(=O)OC(C)(C)C)c(NC2CC2)c(F)c1N1CCC(NC(=O)OC(C)(C)C)C1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SUV39H2 Q9H5I1 17/20 0.40
KDM4D Q6B0I6 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7511874 0.89 SUV39H2 (0.38) SUV39H2KDM4D
SCHEMBL4515963 0.88 SUV39H2 (0.43) SUV39H2KDM4D
SCHEMBL4514471 0.86 SUV39H2 (0.41) SUV39H2KDM4D
SCHEMBL4713638 0.85 BTK (0.39) KDM4D
SCHEMBL4519007 0.84 SUV39H2 (0.40) SUV39H2KDM4D
SCHEMBL7554372 0.84 KDM4D (0.38) SUV39H2KDM4D
SCHEMBL7514128 0.83 CTSK (0.39) SUV39H2KDM4D
SCHEMBL7514351 0.82 KDM4D (0.35) SUV39H2KDM4D
SCHEMBL7516546 0.81 BTK (0.39) SUV39H2KDM4D
SCHEMBL5835111 0.78 CTSK (0.41) SUV39H2KDM4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1255739-A1 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 2002-11-13 EP disclosed
WO-2001053273-A1 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 2001-07-26 WO disclosed