Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511753 | 0.88 | PIK3CD (0.44) | ALDH1A1POLBPDE4BPDE7ASMN1; SMN2 | |
| SCHEMBL7521856 | 0.83 | GRM1 (0.36) | ALDH1A1CYP2D6CYP2C19POLBSMN1; SMN2 | |
| SCHEMBL7518257 | 0.83 | POLB (0.43) | ALDH1A1CYP2D6CYP2C19POLBTSHR | |
| SCHEMBL7512387 | 0.81 | ALDH1A1 (0.42) | ALDH1A1CYP2D6CYP2C19POLBTSHR | |
| SCHEMBL6219083 | 0.79 | ALDH1A1 (0.45) | ALDH1A1CYP2D6CYP2C19POLBTSHR | |
| SCHEMBL7509792 | 0.77 | POLB (0.41) | ALDH1A1CYP2D6CYP2C19POLBTSHR | |
| SCHEMBL7507689 | 0.77 | RXFP1 (0.44) | ALDH1A1CYP2D6CYP2C19POLBTSHR | |
| SCHEMBL7510642 | 0.76 | POLB (0.46) | ALDH1A1CYP2D6CYP2C19POLBTSHR | |
| SCHEMBL7510608 | 0.75 | LMNA (0.44) | ALDH1A1CYP2D6CYP2C19PDE4BPDE7A | |
| SCHEMBL6218525 | 0.72 | ALDH1A1 (0.64) | ALDH1A1CYP2D6CYP2C19POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807633-B1 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-0807633-A2 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER INC. (US) | 1997-11-19 | — | — | EP | disclosed |