Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6222400 | 0.87 | MEN1 (0.69) | MEN1KMT2ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7518263 | 0.87 | LMNA (0.47) | TP53SMN1; SMN2POLBALDH1A1PDE4B | |
| SCHEMBL6219540 | 0.83 | TP53 (0.71) | MEN1KMT2ATP53MAPTSMN1; SMN2 | |
| SCHEMBL6219542 | 0.83 | TP53 (0.71) | MEN1KMT2ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7511761 | 0.82 | MEN1 (0.52) | MEN1KMT2ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7510635 | 0.82 | TP53 (0.55) | MEN1KMT2ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7511492 | 0.82 | TP53 (0.55) | MEN1KMT2ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7510646 | 0.82 | TP53 (0.55) | MEN1KMT2ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7514701 | 0.82 | TP53 (0.58) | MEN1KMT2ATP53MAPTSMN1; SMN2 | |
| SCHEMBL7511484 | 0.82 | TP53 (0.55) | MEN1KMT2ATP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807633-B1 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-0807633-A2 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER INC. (US) | 1997-11-19 | — | — | EP | disclosed |