Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7522650 | 0.88 | LMNA (0.44) | LMNATP53NR1H2ALDH1A1CYP2D6 | |
| SCHEMBL6224299 | 0.87 | MEN1 (0.52) | LMNATP53POLB | |
| SCHEMBL7511220 | 0.87 | MEN1 (0.52) | TP53NR1H2PDE4BPDE7APOLB | |
| SCHEMBL6214102 | 0.83 | ALDH1A1 (0.46) | LMNATP53TSHRPDE4BPDE7A | |
| SCHEMBL6222276 | 0.83 | LMNA (0.54) | LMNATP53 | |
| SCHEMBL6222277 | 0.83 | LMNA (0.54) | LMNATP53 | |
| SCHEMBL7510608 | 0.82 | LMNA (0.44) | LMNATP53PDE4BPDE7AALDH1A1 | |
| SCHEMBL7512385 | 0.82 | KMT2A (0.57) | LMNATP53POLBALDH1A1CYP2D6 | |
| SCHEMBL7512391 | 0.82 | KMT2A (0.57) | LMNATP53POLBALDH1A1CYP2D6 | |
| SCHEMBL6219085 | 0.81 | LMNA (0.45) | LMNATP53TSHRPDE4BPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807633-B1 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-0807633-A2 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER INC. (US) | 1997-11-19 | — | — | EP | disclosed |