Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 7/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7522638 | 1.00 | ALDH1A1 (0.35) | ALDH1A1TSHRHTTKCNA5MEN1 | |
| SCHEMBL7510394 | 0.86 | ATM (0.40) | ALDH1A1HTTKCNA5MEN1KMT2A | |
| SCHEMBL7521180 | 0.86 | ATM (0.40) | ALDH1A1HTTKCNA5MEN1KMT2A | |
| SCHEMBL7519235 | 0.84 | MEN1 (0.37) | ALDH1A1HTTKCNA5MEN1KMT2A | |
| SCHEMBL7512991 | 0.84 | MEN1 (0.37) | ALDH1A1HTTKCNA5MEN1KMT2A | |
| SCHEMBL7519458 | 0.81 | ATM (0.37) | ALDH1A1HTTKCNA5MEN1KMT2A | |
| SCHEMBL6828018 | 0.81 | ATM (0.37) | ALDH1A1HTTKCNA5MEN1KMT2A | |
| SCHEMBL7518623 | 0.79 | HTT (0.40) | ALDH1A1HTTKCNA5MEN1KMT2A | |
| SCHEMBL7515008 | 0.78 | KCNA5 (0.39) | ALDH1A1HTTKCNA5MEN1KMT2A | |
| SCHEMBL7520967 | 0.78 | KCNA5 (0.39) | ALDH1A1HTTKCNA5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126836-A4 | BENZAMIDE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1126836-A1 | BENZAMIDE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000025774-A1 | BENZAMIDE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |