SCHEMBL6828018

SCHEMBL6828018

COc1ccccc1[C@@](CCCO)(CNC=O)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.37
GAA P10253 3/20 0.36
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
ALDH1A1 P00352 3/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
HSD17B10 Q99714 1/20 0.34
HTT P42858 1/20 0.34
NR3C2 P08235 1/20 0.34
KCNA5 P22460 2/20 0.34
EGFR P00533 1/20 0.34
MMP1 P03956 1/20 0.34
MMP2 P08253 1/20 0.34
MMP9 P14780 1/20 0.34
TRPV1 Q8NER1 1/20 0.33
KDM4E B2RXH2 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7519458 1.00 ATM (0.37) ATMGAAMEN1KMT2AALDH1A1
SCHEMBL7512991 0.86 MEN1 (0.37) ATMGAAMEN1KMT2AALDH1A1
SCHEMBL7519235 0.86 MEN1 (0.37) ATMGAAMEN1KMT2AALDH1A1
SCHEMBL7521180 0.84 ATM (0.40) ATMGAAMEN1KMT2AALDH1A1
SCHEMBL7510394 0.84 ATM (0.40) ATMGAAMEN1KMT2AALDH1A1
SCHEMBL7823386 0.83 ADH1B (0.38) ATMGAAMEN1KMT2AALDH1A1
SCHEMBL7824381 0.83 KIF11 (0.43) MEN1KMT2AALDH1A1SMN1; SMN2HTT
SCHEMBL7822809 0.82 CCR3 (0.37) ATMGAAMEN1KMT2AALDH1A1
SCHEMBL7512155 0.81 ALDH1A1 (0.35) ATMGAAMEN1KMT2AALDH1A1
SCHEMBL7522638 0.81 ALDH1A1 (0.35) ATMGAAMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1368020-A4 METHOD FOR IDENTIFYING MAXI-K CHANNEL BLOCKERS MERCK & CO INC (US) 2004-05-12 EP claimed
EP-1368020-A2 METHOD FOR IDENTIFYING MAXI-K CHANNEL BLOCKERS Merck & Co., Inc. (US) 2003-12-10 EP claimed
WO-2002060340-A9 METHOD FOR IDENTIFYING MAXI-K CHANNEL BLOCKERS MERCK & CO INC (US) 2002-11-21 WO claimed
EP-1126836-A4 BENZAMIDE POTASSIUM CHANNEL INHIBITORS MERCK & CO INC (US) 2002-09-04 EP claimed
WO-2002060340-A2 METHOD FOR IDENTIFYING MAXI-K CHANNEL BLOCKERS MERCK & CO., INC. (US) 2002-08-08 WO claimed
EP-1126836-A1 BENZAMIDE POTASSIUM CHANNEL INHIBITORS Merck & Co., Inc. (US) 2001-08-29 EP claimed
WO-2000025774-A1 BENZAMIDE POTASSIUM CHANNEL INHIBITORS MERCK & CO., INC. (US) 2000-05-11 WO claimed
EP-1368020-A4 METHOD FOR IDENTIFYING MAXI-K CHANNEL BLOCKERS MERCK & CO INC (US) 2004-05-12 EP disclosed
EP-1368020-A2 METHOD FOR IDENTIFYING MAXI-K CHANNEL BLOCKERS Merck & Co., Inc. (US) 2003-12-10 EP disclosed
EP-1126836-A4 BENZAMIDE POTASSIUM CHANNEL INHIBITORS MERCK & CO INC (US) 2002-09-04 EP disclosed
WO-2002060340-A2 METHOD FOR IDENTIFYING MAXI-K CHANNEL BLOCKERS MERCK & CO., INC. (US) 2002-08-08 WO disclosed
EP-1126836-A1 BENZAMIDE POTASSIUM CHANNEL INHIBITORS Merck & Co., Inc. (US) 2001-08-29 EP disclosed
WO-2000025774-A1 BENZAMIDE POTASSIUM CHANNEL INHIBITORS MERCK & CO., INC. (US) 2000-05-11 WO disclosed