Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.62 |
| ▸ | PDE2A | O00408 | 1/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | PDE5A | O76074 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19792401 | 0.87 | KDM4E (0.62) | MAPK1SMN1; SMN2ALDH1A1LMNACYP3A4 | |
| SCHEMBL23457461 | 0.86 | PDE10A (0.53) | MAPK1SMN1; SMN2ALDH1A1LMNACYP3A4 | |
| SCHEMBL7516352 | 0.86 | MAPK1 (0.51) | MAPK1SMN1; SMN2ALDH1A1LMNACYP3A4 | |
| SCHEMBL7513679 | 0.86 | APP (0.60) | MAPK1SMN1; SMN2ALDH1A1LMNACYP3A4 | |
| SCHEMBL7516992 | 0.86 | MAPK1 (0.63) | MAPK1SMN1; SMN2ALDH1A1LMNACYP3A4 | |
| SCHEMBL19797771 | 0.86 | RET (0.56) | MAPK1SMN1; SMN2ALDH1A1LMNACYP3A4 | |
| SCHEMBL7510762 | 0.86 | EGFR (0.58) | MAPK1SMN1; SMN2ALDH1A1LMNACYP3A4 | |
| SCHEMBL6183340 | 0.85 | EGFR (0.61) | MAPK1LMNAACHEKDM4EHPGD | |
| Hydrochloric Acid SCHEMBL7522378 | 0.85 | APP (0.59) | MAPK1SMN1; SMN2ALDH1A1LMNACYP3A4 | |
| Hydrochloric Acid SCHEMBL7511516 | 0.85 | APP (0.59) | MAPK1SMN1; SMN2ALDH1A1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | claimed |
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | disclosed |