Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.63 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 5/20 | 0.55 |
| ▸ | CSF1R | P07333 | 2/20 | 0.55 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19792401 | 0.87 | KDM4E (0.62) | MAPK1ACHEBACE1KDREGFR | |
| SCHEMBL7516352 | 0.86 | MAPK1 (0.51) | MAPK1ACHEBACE1FLT1KDR | |
| SCHEMBL7510762 | 0.86 | EGFR (0.58) | MAPK1ACHEBACE1KDREGFR | |
| SCHEMBL19797771 | 0.86 | RET (0.56) | MAPK1ACHEFLT1KDREGFR | |
| SCHEMBL6183340 | 0.86 | EGFR (0.61) | MAPK1ACHEBACE1KDREGFR | |
| SCHEMBL7512207 | 0.86 | MAPK1 (0.62) | MAPK1ACHEEGFRCSF1RHTT | |
| SCHEMBL16585401 | 0.85 | MAPK1 (0.65) | MAPK1EGFRCSF1RENPP1HTT | |
| SCHEMBL7510839 | 0.83 | KIT (0.60) | MAPK1EGFRHTTPDGFRBPDGFRA | |
| SCHEMBL7517324 | 0.83 | KIT (0.60) | KDREGFRCSF1RHTTMEN1 | |
| SCHEMBL18158153 | 0.82 | EGFR (0.60) | MAPK1KDREGFRCSF1RHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | claimed |