Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 10/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 8/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7516992 | 0.86 | MAPK1 (0.63) | MAPK1KDREGFRENPP1CYP1A2 | |
| SCHEMBL7512207 | 0.86 | MAPK1 (0.62) | MAPK1EGFRCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL16585401 | 0.83 | MAPK1 (0.65) | MAPK1EGFRENPP1CYP1A2CYP3A4 | |
| SCHEMBL19792401 | 0.82 | KDM4E (0.62) | MAPK1KDREGFRCYP1A2CYP3A4 | |
| SCHEMBL7510762 | 0.81 | EGFR (0.58) | MAPK1KDRERBB2EGFRCYP1A2 | |
| SCHEMBL19797771 | 0.81 | RET (0.56) | MAPK1KDREGFRCYP1A2CYP3A4 | |
| SCHEMBL6183340 | 0.81 | EGFR (0.61) | MAPK1KDREGFRACHELMNA | |
| SCHEMBL7510839 | 0.78 | KIT (0.60) | MAPK1EGFRALDH1A1PDE3BPDE3A | |
| SCHEMBL7517324 | 0.78 | KIT (0.60) | KDREPHA2EPHB4ERBB2EGFR | |
| SCHEMBL6273407 | 0.78 | EGFR (0.57) | MAPK1KDRERBB2EGFRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | claimed |
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | disclosed |