SCHEMBL7512352

SCHEMBL7512352

CCCCCCCCCCc1nnnn1CC(=O)O

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 1/20 0.47
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
SCD O00767 1/20 0.39
LMNA P02545 1/20 0.39
TSHR P16473 1/20 0.39
CDC25A P30304 2/20 0.39
CDC25B P30305 2/20 0.39
CDC25C P30307 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11802408 0.98 KDM4C (0.48) KDM4CALDH1A1HPGD
SCHEMBL28695451 0.87 KDM4C (0.51) KDM4CALDH1A1HPGDLMNA
SCHEMBL7511517 0.82 MAPK1 (0.60) ALDH1A1
SCHEMBL4409151 0.80 ALDH1A1 (0.40) ALDH1A1LMNATSHR
SCHEMBL28712651 0.79 GPR84 (0.42) ALDH1A1TSHR
SCHEMBL28695455 0.79 GPR84 (0.42) ALDH1A1TSHR
SCHEMBL7507454 0.79 GPR84 (0.42) ALDH1A1TSHR
SCHEMBL28711303 0.79 GPR84 (0.42) ALDH1A1TSHR
SCHEMBL28703274 0.79 GPR84 (0.42) ALDH1A1TSHR
SCHEMBL28711311 0.79 GPR84 (0.42) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1203767-A1 Heterocyclic-substituted alkylamide acat inhibitors WARNER-LAMBERT COMPANY (US) 2002-05-08 EP disclosed
US-5693657-A USEFUL FOR TREATING HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS WARNER-LAMBERT COMPANY (US) 1997-12-02 US disclosed
US-5646170-A ACYLCOENZYME A:CHOLESTEROL ACYLTRANSFERASE INHIBITORS WARNER-LAMBERT COMPANY (US) 1997-07-08 US disclosed
EP-0600950-B1 AMIDE TETRAZOLE ACAT INHIBITORS WARNER LAMBERT CO (US) 1996-10-23 EP disclosed
EP-0684945-A1 HETEROCYCLIC-SUBSTITUTED ALKYL AMIDE ACAT INHIBITORS WARNER-LAMBERT COMPANY (US) 1995-12-06 EP disclosed
US-5441975-A Anticholesterol agent WARNER-LAMBERT COMPANY (US) 1995-08-15 US disclosed
US-5366987-A Enzyme inhibitors, anticholesterol WARNER-LAMBERT COMPANY (US) 1994-11-22 US disclosed
WO-1994019330-A1 HETEROCYCLIC-SUBSTITUTED ALKYL AMIDE ACAT INHIBITORS WARNER-LAMBERT COMPANY (US) 1994-09-01 WO disclosed
EP-0600950-A1 AMIDE TETRAZOLE ACAT INHIBITORS. WARNER LAMBERT CO (US) 1994-06-15 EP disclosed
WO-1993004052-A1 AMIDE TETRAZOLE ACAT INHIBITORS WARNER-LAMBERT COMPANY (US) 1993-03-04 WO disclosed