Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7504271 | 0.92 | KDM4E (0.47) | MEN1KMT2AKDM4ETP53 | |
| SCHEMBL7503892 | 0.90 | KDM4E (0.45) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7507912 | 0.90 | ALDH1A1 (0.47) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7498695 | 0.89 | KDM4E (0.44) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL7505821 | 0.89 | KDM4E (0.50) | MEN1KMT2AKDM4ENHERF1 | |
| SCHEMBL7503003 | 0.88 | KDM4E (0.54) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7508559 | 0.88 | KDM4E (0.43) | MEN1KMT2AKDM4ETP53 | |
| SCHEMBL7502875 | 0.88 | KDM4E (0.43) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7502863 | 0.88 | KDM4E (0.43) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL7508136 | 0.88 | ALOX15 (0.44) | MAPTL3MBTL1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |