Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.63 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517471 | 0.88 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11PTK6 | |
| SCHEMBL7516166 | 0.86 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11PTK6 | |
| SCHEMBL7039491 | 0.85 | MAPK13 (0.55) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL7039292 | 0.85 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7033526 | 0.83 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7034034 | 0.81 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7036407 | 0.79 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL5173634 | 0.79 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1904637 | 0.78 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7034038 | 0.78 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | claimed |
| US-20020016347-A1 | Benzophenones as inhibitors of IL-1beta and TNF-alpha | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-02-07 | — | — | US | claimed |
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | disclosed |
| US-20020016347-A1 | Benzophenones as inhibitors of IL-1beta and TNF-alpha | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016347-A1 | Benzophenones as inhibitors of IL-1beta and TNF-alpha | IL1B, IL1A, NFKBIA | MAPK14 625/4885MAPK13 1908/4885MAPK12 1184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.