SCHEMBL7513086

SCHEMBL7513086

CC(C)(C)[Si](C)(C)[Si](C)(C)C(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.41
ALDH1A1 P00352 3/20 0.38
TAAR1 Q96RJ0 1/20 0.38
ALOX15 P16050 1/20 0.38
ESR1 P03372 2/20 0.37
ESR2 Q92731 2/20 0.37
CYP3A4 P08684 1/20 0.37
KCNN4 O15554 3/20 0.36
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
TSHR P16473 2/20 0.35
CYP2C19 P33261 1/20 0.34
HIF1A Q16665 1/20 0.34
NR1H2 P55055 1/20 0.33
NR1H3 Q13133 1/20 0.33
CYP2B6 P20813 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3743994 0.70 KCNN4 (0.39) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL6602971 0.70 ALDH1A1 (0.41) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL6324964 0.70 TSHR (0.43) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL10332647 0.70 KCNN4 (0.43) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL6322919 0.70 TSHR (0.43) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL6860477 0.70 ALDH1A1 (0.43) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL10332646 0.70 KCNN4 (0.39) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL6602963 0.70 ALDH1A1 (0.39) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL22730167 0.70 MAPK1 (0.39) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL6226453 0.70 MAPK1 (0.39) MAPK1ALDH1A1TAAR1ALOX15ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0677527-B1 Process for preparing 2,2-difluoroketene silyl O,S-acetals and alpha, alpha-difluoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid O,S-esters LILLY CO ELI (US) 2002-01-16 EP claimed
EP-0655454-B1 Process for preparing 2,2-difluoroketene silyl acetals and alpha,alpha-difluoro-beta-silyloxy-1,3-dioxolane-4-propanoic acid esters LILLY CO ELI (US) 2001-08-16 EP claimed
US-5618951-A REACTING A CHLORODIFLUOROACETATE WITH A HALOSILANE USING AN UREA SILVENT AND A REDUCING AGENT ELI LILLY AND COMPANY (US) 1997-04-08 US claimed
US-5618951-A REACTING A CHLORODIFLUOROACETATE WITH A HALOSILANE USING AN UREA SILVENT AND A REDUCING AGENT ELI LILLY AND COMPANY (US) 1997-04-08 US disclosed