Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 4/20 | 0.57 |
| ▸ | FPR3 | P25089 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12961110 | 0.92 | HTT (0.61) | POLBHTTALDH1A1KDM4ECNR1 | |
| SCHEMBL24381846 | 0.91 | POLB (0.65) | FPR2FPR3POLBHTTALDH1A1 | |
| SCHEMBL14608288 | 0.86 | HTT (0.56) | POLBHTTALDH1A1KDM4ECNR1 | |
| SCHEMBL16383171 | 0.86 | HTT (0.56) | POLBHTTALDH1A1CNR1HDAC3 | |
| SCHEMBL7505669 | 0.85 | CNR1 (0.63) | POLBHTTCNR1NPC1RAB9A | |
| SCHEMBL14574172 | 0.85 | HTT (0.55) | POLBHTTALDH1A1HDAC3HDAC4 | |
| SCHEMBL7507650 | 0.84 | EPHX1 (0.65) | POLBHTTALDH1A1KDM4ECNR1 | |
| SCHEMBL27911572 | 0.84 | ALDH1A1 (0.58) | FPR2FPR3ALDH1A1KDM4ECNR1 | |
| SCHEMBL15344370 | 0.84 | NAMPT (0.56) | POLBHTTHDAC3HDAC4HDAC1 | |
| SCHEMBL4116418 | 0.83 | MEN1 (0.52) | FPR2FPR3POLBHTTCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237849-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001032604-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2001-05-10 | — | — | WO | disclosed |