SCHEMBL751327

SCHEMBL751327

Cc1cc(C[Si](C)(C)C)cc(C[Si](C)(C)C)c1

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.42
PGK1 P00558 1/20 0.39
PGK2 P07205 1/20 0.39
CA1 P00915 1/20 0.33
CA9 Q16790 1/20 0.33
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33
HPGD P15428 1/20 0.32
NOS1 P29475 2/20 0.31
NOS2 P35228 2/20 0.31
ALDH1A1 P00352 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL748390 0.94 ESR1 (0.42) ESR1PGK1PGK2CA1CA9
SCHEMBL747995 0.88 ESR1 (0.50) ESR1
SCHEMBL7754170 0.75 TAAR1 (0.52) ESR1CYP11B1CYP11B2ALDH1A1
SCHEMBL986310 0.72 ESR1 (0.61) ESR1CA1CA9CYP11B1CYP11B2
SCHEMBL5692149 0.72 ESR1 (0.38) ESR1
SCHEMBL5488290 0.70 CYP11B1 (0.36) PGK1PGK2CYP11B1CYP11B2HPGD
SCHEMBL3949041 0.69 ESR1 (0.74) ESR1ALDH1A1
SCHEMBL16809251 0.69 CYP11B1 (0.35) PGK1PGK2CYP11B1CYP11B2HPGD
SCHEMBL28671562 0.69 CYP11B1 (0.35) PGK1PGK2CA1CA9CYP11B1
SCHEMBL5490825 0.67 PGK1 (0.44) PGK1PGK2CYP11B1CYP11B2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3263605-B1 METHOD FOR PREPARING MODIFIED CONJUGATED DIENE RUBBER ZEON CORP (JP) 2019-11-13 EP disclosed
US-10414835-B2 Method of production of modified conjugated diene rubber ZEON CORPORATION (JP) 2019-09-17 US disclosed
EP-2431395-B1 METHOD FOR PRODUCING RADIAL CONJUGATED DIENE POLYMER ZEON CORP (JP) 2018-03-21 EP disclosed
EP-2980111-B1 METHOD FOR PRODUCING RADIAL CONJUGATED DIENE RUBBER ZEON CORP (JP) 2018-01-31 EP disclosed
US-20180016362-A1 METHOD OF PRODUCTION OF MODIFIED CONJUGATED DIENE RUBBER ZEON CORPORATION (JP) 2018-01-18 US disclosed
EP-3263605-A1 METHOD FOR PREPARING MODIFIED CONJUGATED DIENE RUBBER Zeon Corporation (JP) 2018-01-03 EP disclosed
EP-2799454-B1 METHOD FOR PRODUCING MODIFIED CONJUGATED DIENE RUBBER ZEON CORP (JP) 2017-07-12 EP disclosed
US-9428596-B2 Method of production of modified conjugated diene-based rubber ZEON CORPORATION (JP) 2016-08-30 US disclosed
US-20160053033-A1 METHOD OF PRODUCTION OF RADIAL CONJUGATED DIENE RUBBER ZEON CORPORATION (JP) 2016-02-25 US disclosed
EP-2980111-A1 METHOD FOR PRODUCING RADIAL CONJUGATED DIENE RUBBER Zeon Corporation (JP) 2016-02-03 EP disclosed
US-8993675-B2 Method of production of radial conjugated diene polymer ZEON CORPORATION (JP) 2015-03-31 US disclosed
US-20140364559-A1 METHOD OF PRODUCTION OF MODIFIED CONJUGATED DIENE-BASED RUBBER ZEON CORPORATION (JP) 2014-12-11 US disclosed
EP-2799454-A1 METHOD FOR PRODUCING MODIFIED CONJUGATED DIENE RUBBER Zeon Corporation (JP) 2014-11-05 EP disclosed
US-20120071603-A1 METHOD OF PRODUCTION OF RADIAL CONJUGATED DIENE POLYMER ZEON CORPORATION (JP) 2012-03-22 US disclosed
EP-2431395-A1 METHOD FOR PRODUCING RADIAL CONJUGATED DIENE POLYMER Zeon Corporation (JP) 2012-03-21 EP disclosed