Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5115389 | 0.97 | PDE5A (0.42) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5122637 | 0.89 | SMN1; SMN2 (0.46) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5123408 | 0.87 | PDE5A (0.46) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5114649 | 0.85 | PDE5A (0.54) | PDE5AKCNN3KMT2AMEN1MAPT | |
| SCHEMBL5131068 | 0.83 | PDE5A (0.52) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7512863 | 0.83 | PTGS2 (0.44) | — | |
| SCHEMBL5122690 | 0.82 | ADORA2A (0.46) | PDE5AKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL5128984 | 0.82 | PDE5A (0.44) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7510478 | 0.82 | ALDH1A1 (0.41) | POLBALDH1A1ADORA2AADORA1RXFP1 | |
| SCHEMBL5129167 | 0.81 | PDE5A (0.48) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |