Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | RAD52 | P43351 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7513935 | 1.00 | MAPK1 (0.52) | MAPK1HTTSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL847480 | 0.93 | MAPK1 (0.51) | MAPK1HTTSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL847415 | 0.83 | KMT2A (0.45) | MAPK1HTTSMN1; SMN2KMT2ALMNA | |
| SCHEMBL847404 | 0.80 | SMN1; SMN2 (0.57) | MAPK1HTTSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL7508444 | 0.77 | ALDH1A1 (0.81) | MAPK1HTTSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL12015276 | 0.74 | KMT2A (0.75) | SMN1; SMN2KMT2ALMNAMEN1TDP1 | |
| SCHEMBL2458059 | 0.72 | HDAC3 (0.53) | HTTMAPTALDH1A1CYP1A2HDAC3 | |
| SCHEMBL2458057 | 0.72 | HDAC3 (0.53) | HTTMAPTALDH1A1CYP1A2HDAC3 | |
| SCHEMBL22645349 | 0.71 | MAPT (0.55) | MAPK1HTTSMN1; SMN2KMT2AMAPT | |
| SCHEMBL27569641 | 0.70 | HDAC3 (0.50) | MAPK1SMN1; SMN2KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237849-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2002-09-11 | — | — | EP | claimed |
| WO-2001032604-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2001-05-10 | — | — | WO | claimed |