Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8137810 | 0.87 | HPGD (0.56) | ALDH1A1KMT2AMEN1TSHRMAPK1 | |
| SCHEMBL2450846 | 0.85 | ALDH1A1 (0.58) | ALDH1A1KMT2AMEN1TSHRMAPK1 | |
| SCHEMBL2079317 | 0.84 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1TSHRMAPK1 | |
| SCHEMBL18788570 | 0.82 | GSK3B (0.45) | ALDH1A1KMT2AMEN1MAPK1MAPT | |
| SCHEMBL2080107 | 0.81 | ALDH1A1 (0.52) | ALDH1A1KMT2ATSHRMAPK1SMN1; SMN2 | |
| SCHEMBL10715141 | 0.80 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1TSHRMAPK1 | |
| SCHEMBL8138933 | 0.80 | GSK3B (0.42) | ALDH1A1KMT2AMEN1TSHRMAPK1 | |
| SCHEMBL40329 | 0.80 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1TSHRMAPK1 | |
| SCHEMBL79163 | 0.80 | DTYMK (0.62) | ALDH1A1KMT2AMEN1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL1138798 | 0.78 | DTYMK (0.60) | ALDH1A1KMT2AMEN1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |