SCHEMBL7514428

SCHEMBL7514428

NCc1cccc(CN2CCC(O)C2)c1

nearest known ligand 0.59

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 1/20 0.59
NCF1 P14598 1/20 0.55
ALDH1A1 P00352 1/20 0.55
HTT P42858 1/20 0.46
PDCD1 Q15116 3/20 0.46
CD274 Q9NZQ7 3/20 0.46
LTA4H P09960 5/20 0.44
ROCK2 O75116 1/20 0.43
PARP1 P09874 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4976833 0.91 ALDH1A1 (0.68) PRMT6NCF1ALDH1A1HTTLTA4H
SCHEMBL7761231 0.91 PRMT6 (0.68) PRMT6NCF1ALDH1A1HTT
SCHEMBL13932969 0.85 ALDH1A1 (0.55) ALDH1A1HTTPDCD1CD274LTA4H
SCHEMBL3722397 0.85 ALDH1A1 (0.55) ALDH1A1HTTPDCD1CD274LTA4H
SCHEMBL25212788 0.82 ALDH1A1 (0.58) ALDH1A1
SCHEMBL8212538 0.82 BCHE (0.56) ALDH1A1HTTPDCD1CD274
SCHEMBL29864671 0.82 ALDH1A1 (0.58) ALDH1A1
SCHEMBL19710807 0.82 BCHE (0.56) ALDH1A1HTTPDCD1CD274
SCHEMBL608225 0.80 ALDH1A1 (0.81) ALDH1A1LTA4H
SCHEMBL741364 0.80 ALDH1A1 (0.81) ALDH1A1LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3194397-A1 2-[BIS(4-FLUOROPHENYL)METHYL]-2,7-DIAZASPIRO[4.5]DECAN-10-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN DOPAMINE-ACTIVE-TRANSPORTER (DAT) PROTEIN FOR THE TREATMENT OF E.G. ATTENTION DEFICIT DISORDER (ADD) Chronos Therapeutics Limited (GB) 2017-07-26 EP disclosed
EP-3194385-A1 N-(HETERO)ARYL-SUBSTITUTED HETEROYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES OR CONDITIONS RELATED TO THE CENTRAL NERVOUS SYSTEM Chronos Therapeutics Limited (GB) 2017-07-26 EP disclosed
WO-2016042453-A1 N-(HETERO)ARYL-SUBSTITUTED HETEROYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES OR CONDITIONS RELATED TO THE CENTRAL NERVOUS SYSTEM SHIRE INTERNATIONAL GMBH (CH) 2016-03-24 WO disclosed
WO-2016042451-A1 2-[BIS(4-FLUOROPHENYL)METHYL]-2,7-DIAZASPIRO[4.5]DECAN-10-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN DOPAMINE-ACTIVE-TRANSPORTER (DAT) PROTEIN FOR THE TREATMENT OF E.G. ATTENTION DEFICIT DISORDER (ADD) SHIRE INTERNATIONAL GMBH (CH) 2016-03-24 WO disclosed
EP-1255739-A1 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 2002-11-13 EP disclosed
WO-2001053273-A1 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 2001-07-26 WO disclosed