Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 4/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852811 | 0.82 | IDO1 (0.49) | IDO1TDO2GSK3BKDM4EMAPT | |
| SCHEMBL5858697 | 0.77 | CACNB4 (0.47) | IDO1TDO2MAPTCACNB4CACNA1A | |
| SCHEMBL3078111 | 0.76 | JAK2 (0.53) | IDO1TDO2JAK2GSK3BKDM4E | |
| SCHEMBL30564910 | 0.76 | JAK2 (0.53) | IDO1TDO2JAK2GSK3BKDM4E | |
| SCHEMBL16634786 | 0.73 | MAPT (0.49) | IDO1TDO2MAPTCACNB4CACNA1A | |
| SCHEMBL5435436 | 0.73 | MAPT (0.56) | IDO1MAPTCACNB4CACNA1ACACNA1G | |
| SCHEMBL4589633 | 0.72 | TSHR (0.41) | IDO1KDM4EMAPTCACNB4CACNA1A | |
| SCHEMBL7471103 | 0.71 | MAPT (0.41) | IDO1CA1CA2KDM4EMAPT | |
| SCHEMBL5678203 | 0.71 | MAPT (0.44) | IDO1CA12CA1CA2CA9 | |
| SCHEMBL281695 | 0.71 | RAB9A (0.48) | IDO1TDO2MAPTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020102608-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2002-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020102608-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | PTPRJ, ERBB2, JAK2 | ESR1 1189/4885IDO1 95/4885TDO2 486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.