Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.42 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5435436 | 0.85 | MAPT (0.56) | IDO1TSHRCACNB4CACNA1ACACNA1G | |
| SCHEMBL4589633 | 0.84 | TSHR (0.41) | IDO1SMN1; SMN2TSHRKDM4EALDH1A1 | |
| SCHEMBL7514744 | 0.82 | ESR1 (0.41) | IDO1SMN1; SMN2KDM4EGSK3BCACNB4 | |
| SCHEMBL5678203 | 0.82 | MAPT (0.44) | IDO1SMN1; SMN2TSHRKDM4EALDH1A1 | |
| SCHEMBL7471103 | 0.82 | MAPT (0.41) | IDO1SMN1; SMN2TSHRKDM4EALDH1A1 | |
| SCHEMBL4589629 | 0.80 | SMN1; SMN2 (0.40) | SMN1; SMN2TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL5674294 | 0.79 | BRD4 (0.41) | SMN1; SMN2TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL7469707 | 0.79 | BRD4 (0.41) | SMN1; SMN2TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL5431073 | 0.79 | CDYL2 (0.43) | SMN1; SMN2TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL4590172 | 0.78 | HTR2C (0.41) | SMN1; SMN2TSHRKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105376-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010975-A1 | OXINDOLE DERIVATIVES AS GROWTH HORMONE RELEASERS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2000-03-02 | — | — | WO | disclosed |