Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.40 |
| ▸ | BCL2 | P10415 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7503922 | 0.82 | KDM4E (0.43) | TP53SMN1; SMN2ALOX15BCL2MCL1 | |
| SCHEMBL6169641 | 0.82 | PTGS2 (0.59) | BCL2MCL1PTGS2 | |
| SCHEMBL7629398 | 0.82 | ABCB11 (0.43) | TP53SMN1; SMN2ALOX15BCL2MCL1 | |
| SCHEMBL6168423 | 0.81 | PTGS2 (0.46) | TP53SMN1; SMN2BCL2MCL1NOS1 | |
| SCHEMBL7508086 | 0.81 | GRM4 (0.42) | TP53SMN1; SMN2PTGS2 | |
| SCHEMBL8115883 | 0.80 | KDM4E (0.37) | TP53SMN1; SMN2ALOX15PTGS2 | |
| SCHEMBL27569416 | 0.79 | PTGS2 (0.47) | BCL2MCL1PTGS2 | |
| SCHEMBL6948992 | 0.79 | PTGS2 (0.52) | ALOX15PTGS2 | |
| SCHEMBL6946077 | 0.78 | PTGS2 (0.46) | ALOX15PTGS2 | |
| SCHEMBL7512342 | 0.77 | MAP2K1 (0.44) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-B1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6300363-B1 | USEFUL IN THE TREATMENT OR ALLEVIATION OF INFLAMMATION AND OTHER INFLAMMATION ASSOCIATED DISORDERS IN MAMMALS | PFIZER INC. | 2001-10-09 | — | — | US | disclosed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |