Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silver SCHEMBL333097 | 0.96 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1LMNA | |
| SCHEMBL143876 | 0.93 | ALDH1A1 (0.50) | ALDH1A1MAPK1RAB9ANPC1LMNA | |
| SCHEMBL11707018 | 0.93 | ALDH1A1 (0.50) | ALDH1A1MAPK1RAB9ANPC1LMNA | |
| Benzene SCHEMBL31091106 | 0.93 | ALDH1A1 (0.50) | ALDH1A1MAPK1RAB9ANPC1LMNA | |
| SCHEMBL135430 | 0.89 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1LMNA | |
| SCHEMBL404594 | 0.89 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1LMNA | |
| SCHEMBL1132217 | 0.89 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1LMNA | |
| Ammonia Solution, Strong SCHEMBL8002765 | 0.89 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1LMNA | |
| Ammonia Solution, Strong SCHEMBL234555 | 0.89 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1LMNA | |
| Phosphine SCHEMBL9242100 | 0.89 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0631130-B1 | Solid-state ion sensor | HITACHI LTD (JP) | 2002-02-20 | — | — | EP | disclosed |
| EP-0833149-A1 | Method for measuring ion concentration | KYOTO DAIICHI KAGAKU CO., LTD. (JP) | 1998-04-01 | — | — | EP | disclosed |
| US-5505836-A | FLOW THROUGH CELL FOR ELECTROCHEMICAL MEASUREMENT OF ION CONCENTRATION IN A SAMPLE | HITACHI, LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0631130-A2 | Solid-state ion sensor | HITACHI, LTD. (JP) | 1994-12-28 | — | — | EP | disclosed |
| EP-0617277-A1 | Ion-selective electrode and process for preparing the same | HITACHI, LTD. (JP) | 1994-09-28 | — | — | EP | disclosed |
| EP-0343210-B1 | ELECTROCHEMICAL ELECTRODES | The Public Health Laboratory Service Board (GB) | 1993-04-28 | — | — | EP | disclosed |
| US-4995960-A | Used in non-aqueous solution, sensing proteins, cells and viruses | PUBLIC HEALTH LABORATORY SERVICE BOARD (GB) | 1991-02-26 | — | — | US | disclosed |
| EP-0343210-A1 | ELECTROCHEMICAL ELECTRODES | The Public Health Laboratory Service Board (GB) | 1989-11-29 | — | — | EP | disclosed |
| WO-1989004958-A1 | ELECTROCHEMICAL ELECTRODES | PUBLIC HEALTH LABORATORY SERVICE BOARD (GB) | 1989-06-01 | — | — | WO | disclosed |