Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silver SCHEMBL7514944 | 0.96 | ALDH1A1 (0.44) | ALDH1A1MAPK1RAB9ANPC1TSHR | |
| SCHEMBL143876 | 0.96 | ALDH1A1 (0.50) | ALDH1A1MAPK1RAB9ANPC1TSHR | |
| SCHEMBL11707018 | 0.96 | ALDH1A1 (0.50) | ALDH1A1MAPK1RAB9ANPC1TSHR | |
| Benzene SCHEMBL31091106 | 0.96 | ALDH1A1 (0.50) | ALDH1A1MAPK1RAB9ANPC1TSHR | |
| Phosphine SCHEMBL9242100 | 0.92 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1TSHR | |
| SCHEMBL225363 | 0.92 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1TSHR | |
| Ammonia Solution, Strong SCHEMBL234555 | 0.92 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1TSHR | |
| Ammonia Solution, Strong SCHEMBL8002765 | 0.92 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1TSHR | |
| SCHEMBL1132217 | 0.92 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1TSHR | |
| Potassium Ion SCHEMBL134847 | 0.92 | ALDH1A1 (0.47) | ALDH1A1MAPK1RAB9ANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 546 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111548483-B | Use of Salen manganese complexes in tandem catalytic reactions involving unsaturated anhydride-epoxy copolymers | 中国科学技术大学 | 2021-08-13 | — | — | CN | claimed |
| CN-111548483-A | Use of Salen manganese complexes in tandem catalytic reactions involving unsaturated anhydride-epoxy copolymers | 中国科学技术大学 | 2020-08-18 | — | — | CN | claimed |
| US-10308563-B2 | Process for producing ethylene oligomers | HANWHA TOTAL PETROCHEMICAL CO., LTD. (KR) | 2019-06-04 | — | — | US | claimed |
| US-20180170827-A1 | PROCESS FOR PRODUCING ETHYLENE OLIGOMERS | HANWHA TOTALENERGIES PETROCHEMICAL CO., LTD. (KR) | 2018-06-21 | — | — | US | claimed |
| US-20180169642-A1 | CATALYST SYSTEM FOR ETHYLENE OLIGOMERIZATION AND METHOD FOR PRODUCING ETHYLENE OLIGOMERIZATION USING THE SAME | HANWHA TOTAL PETROCHEMICAL CO., LTD. (KR) | 2018-06-21 | — | — | US | claimed |
| US-9718898-B1 | Homogeneous polymerization catalyst for alpha olefins | LION COPOLYMER GEISMAR, LLC (US) | 2017-08-01 | — | — | US | claimed |
| US-9718897-B1 | Process for the polymerization or copolymerization of an alpha olefin | LION COPOLYMER GEISMAR, LLC (US) | 2017-08-01 | — | — | US | claimed |
| US-8975202-B2 | Polymerization catalysts and method for preservation of same | IDEMITSU KOSAN CO., LTD. (JP) | 2015-03-10 | — | — | US | claimed |
| US-20120129683-A1 | POLYMERIZATION CATALYSTS AND METHOD FOR PRESERVATION OF SAME | IDEMITSU KOSAN CO., LTD. (JP) | 2012-05-24 | — | — | US | claimed |
| EP-1363955-B1 | MULTINUCLEAR METALLOCENE CATALYST | HONAM PETROCHEMICAL CORP (KR) | 2008-04-09 | — | — | EP | claimed |
| US-6943225-B2 | Multinuclear metallocene catalyst | HONAM PETROCHEMICAL CORPORATION (KR) | 2005-09-13 | — | — | US | claimed |
| EP-1046654-B1 | Olefin polymerization catalysts and olefin polymer production methods using said olefin polymerization catalysts | JSR CORP (JP) | 2005-06-29 | — | — | EP | claimed |
| US-20040072677-A1 | Multinuclear metallocene catalyst | HONAM PETROCHEMICAL CORPORATION (KR) | 2004-04-15 | — | — | US | claimed |
| EP-1363955-A1 | MULTINUCLEAR METALLOCENE CATALYST | Honam Petrochemical Corporation (KR) | 2003-11-26 | — | — | EP | claimed |
| US-6525150-B1 | Such as vanadium 2,2'-thiobis(6-t-butyl-4-methylphenyl) oxychloride complex, trimethylaluminum and N,N-dimethyl-anilinium tetrakis(pentafluorophenyl)borate; high degree of copolymerization | JSR CORPORATION (JP) | 2003-02-25 | — | — | US | claimed |
| WO-2002060964-A1 | MULTINUCLEAR METALLOCENE CATALYST | HONAM PETROCHEMICAL CORPORATION (KR) | 2002-08-08 | — | — | WO | claimed |
| US-6169152-B1 | COPOLYMER OF ETHYLENE AND A POLAR GROUP-CONTAINING CYCLIC OLEFIN COMPRISING ESTER- OR ANHYDRIDE MODIFIED NORBORNENE OR PERHYDRO-2,3-DIDEHYDRO-1,4:5,8-DIMETHANONAPHTHALENE MADE WITH CATALYST SUCH AS 1,5,9-TRIAZACYCLODODECANYLTITANIUM CHLORIDE | JSR CORPORATION (JP) | 2001-01-02 | — | — | US | claimed |
| EP-1046654-A1 | Olefin polymerization catalysts and olefin polymer production methods using said olefin polymerization catalysts | JSR Corporation (JP) | 2000-10-25 | — | — | EP | claimed |
| US-6100352-A | USING A CATALYST CONSISTING OF A TRANSITION METAL COMPOUND, A COMPOUND CAPABLE OF FORMING AN IONIC COMPOUND BY REACTING WITH THE TRANSITION METAL COMPOUND OR AN OXYGEN-CONTAINING COMPOUND SUCH AS ALUMINOXANE | IDEMITSU KOSAN CO., LTD. (JP) | 2000-08-08 | — | — | US | claimed |
| EP-0617277-A1 | Ion-selective electrode and process for preparing the same | HITACHI, LTD. (JP) | 1994-09-28 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308563-B2 | Process for producing ethylene oligomers | OXER1, HAO2, ORC3 | ALDH1A1 1507/4885MAPK1 2584/4885RAB9A 3258/4885 |
| US-20180169642-A1 | CATALYST SYSTEM FOR ETHYLENE OLIGOMERIZATION AND METHOD FOR PRODUCING ETHYLENE OLIGOMERIZATION USING THE SAME | HACL2, HAO2, MSMO1 | ALDH1A1 1614/4885MAPK1 2501/4885RAB9A 3554/4885 |
| US-20180170827-A1 | PROCESS FOR PRODUCING ETHYLENE OLIGOMERS | OXER1, HAO2, ORC3 | ALDH1A1 1507/4885MAPK1 2584/4885RAB9A 3258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.