Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 4/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515426 | 1.00 | ENPP1 (0.47) | ENPP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL6586097 | 0.82 | ENPP1 (0.63) | ENPP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL6586281 | 0.81 | ACHE (0.54) | CYP3A4CYP2C19ACHEMAOB | |
| SCHEMBL6586280 | 0.81 | ACHE (0.54) | CYP3A4CYP2C19ACHEMAOB | |
| SCHEMBL25548688 | 0.74 | CYP2C9 (0.70) | ENPP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL24000743 | 0.71 | ENPP1 (0.74) | ENPP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL8724175 | 0.70 | KDM4E (0.60) | CYP3A4CYP2C19ACHEMAOB | |
| SCHEMBL8724172 | 0.70 | KDM4E (0.60) | CYP3A4CYP2C19ACHEMAOB | |
| Hydrochloric Acid SCHEMBL30088793 | 0.70 | ENPP1 (0.73) | ENPP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL6589989 | 0.70 | CYP11B1 (0.53) | ENPP1CYP3A4CYP2C9TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098886-A1 | PHTHALAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000005219-A1 | PHTHALAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2000-02-03 | — | — | WO | disclosed |