Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.80 |
| ▸ | MEN1 | O00255 | 4/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14112024 | 0.98 | KMT2A (0.77) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL19134233 | 0.92 | LMNA (0.72) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL25893846 | 0.89 | KMT2A (0.73) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL25893880 | 0.86 | KMT2A (0.69) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL14438183 | 0.86 | SMN1; SMN2 (0.60) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL22622723 | 0.86 | SMN1; SMN2 (0.65) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL5123998 | 0.85 | POLB (0.62) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL19134217 | 0.85 | ATF4 (0.86) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL25893839 | 0.85 | SMN1; SMN2 (0.76) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL19659333 | 0.85 | KMT2A (0.69) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4626870-A1 | NONCOVALENT KEAP1-NRF2 SMALL-MOLECULE INHIBITORS | University of Copenhagen (DK) | 2025-10-08 | — | — | EP | disclosed |
| WO-2024115641-A1 | NONCOVALENT KEAP1-NRF2 SMALL-MOLECULE INHIBITORS | UNIVERSITY OF COPENHAGEN (DK) | 2024-06-06 | — | — | WO | disclosed |
| WO-2024115641-A1 | NONCOVALENT KEAP1-NRF2 SMALL-MOLECULE INHIBITORS | UNIVERSITY OF COPENHAGEN (DK) | 2024-06-06 | — | — | WO | disclosed |
| EP-2968347-B1 | MODULATORS OF THE EIF2ALPHA PATHWAY | UNIV CALIFORNIA (US) | 2023-08-02 | — | — | EP | disclosed |
| US-11220477-B2 | Modulators of the eIF2alpha pathway | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-01-11 | — | — | US | disclosed |
| US-10343981-B2 | Modulators of the eIF2alpha pathway | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-07-09 | — | — | US | disclosed |
| US-20170342020-A1 | MODULATORS OF THE EIF2ALPHA PATHWAY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-11-30 | — | — | US | disclosed |
| US-9708247-B2 | Modulators of the eIF2alpha pathway | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-07-18 | — | — | US | disclosed |
| US-20020045548-A1 | Heat-sensitive recording sheet | SAITO CHEMICALS INSTITUTE CO., LTD. (JP) | 2002-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342020-A1 | MODULATORS OF THE EIF2ALPHA PATHWAY | EIF2AK1, EIF2A, EIF2AK3 | KMT2A 3254/4885SMN1; SMN2 534/4885MEN1 4660/4885 |
| US-11220477-B2 | Modulators of the eIF2alpha pathway | EIF2AK1, EIF2A, EIF2AK3 | KMT2A 3254/4885SMN1; SMN2 534/4885MEN1 4660/4885 |
| US-10343981-B2 | Modulators of the eIF2alpha pathway | EIF2AK1, EIF2A, EIF2AK3 | KMT2A 3254/4885SMN1; SMN2 534/4885MEN1 4660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.