Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706091 | 0.80 | CYP1A2 (0.41) | ALDH1A1CYP1A2KDM4E | |
| SCHEMBL7519075 | 0.79 | TDP1 (0.39) | HCAR2EGLN1RXRANR4A2PDE4B | |
| SCHEMBL2743303 | 0.75 | EGLN1 (0.37) | HCAR2EGLN1ALDH1A1KDM4EPOLB | |
| SCHEMBL4913697 | 0.75 | EGLN1 (0.41) | HCAR2EGLN1ALDH1A1 | |
| SCHEMBL5188179 | 0.75 | HCAR2 (0.41) | HCAR2RXRANR4A2PDE4BPDE4D | |
| SCHEMBL10776031 | 0.75 | TSHR (0.41) | HCAR2ALDH1A1LMNACYP2C9ATM | |
| SCHEMBL7824207 | 0.72 | HCAR2 (0.42) | HCAR2EGLN1ALDH1A1KDM4E | |
| SCHEMBL31751932 | 0.69 | TDP1 (0.44) | HCAR2RXRANR4A2PDE4BPDE4D | |
| SCHEMBL6298416 | 0.69 | HCAR2 (0.40) | HCAR2RXRANR4A2PDE4BPDE4D | |
| SCHEMBL5477906 | 0.69 | ALDH1A1 (0.40) | HCAR2EGLN1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863882-B1 | AMINO SUBSTITUTED PYRIMIDINES AND TRIAZINES | JANSSEN PHARMACEUTICA NV (BE) | 2002-02-06 | — | — | EP | disclosed |
| US-6288060-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS; ANXIOLYTIC, ANTIDEPRESSANT, ANTIINFLAMMATORY AGENTS; EATING DISORDERS | NEUROCRINE BIOSCIENCES, INC. | 2001-09-11 | — | — | US | disclosed |