Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 13/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.47 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515812 | 1.00 | DHODH (0.61) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL3250475 | 0.84 | DHODH (0.82) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL3250476 | 0.84 | DHODH (0.82) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL5914902 | 0.84 | DHODH (0.82) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL7517127 | 0.81 | DHODH (0.68) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL7517125 | 0.81 | DHODH (0.68) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL6313989 | 0.77 | GPR35 (0.57) | MEN1KMT2ATSHR | |
| SCHEMBL9079477 | 0.76 | DHODH (0.74) | DHODHMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL3911427 | 0.76 | TDP1 (0.54) | KMT2AALDH1A1GAALMNABLM | |
| SCHEMBL8810371 | 0.76 | DHODH (0.74) | DHODHMEN1KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | claimed |
| EP-0832073-A1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | Sugen, Inc. (US) | 1998-04-01 | — | — | EP | claimed |
| WO-1996040648-A1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | claimed |