⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4214621 | 0.89 | KDM4E (0.31) | — | |
| SCHEMBL4214626 | 0.89 | KDM4E (0.31) | — | |
| SCHEMBL19675562 | 0.87 | KDM4E (0.30) | — | |
| SCHEMBL167234 | 0.86 | — | — | |
| SCHEMBL386745 | 0.81 | — | — | |
| SCHEMBL18570282 | 0.77 | — | — | |
| SCHEMBL18024877 | 0.77 | — | — | |
| SCHEMBL1164553 | 0.75 | KDM4E (0.34) | — | |
| SCHEMBL45941 | 0.75 | KDM4E (0.34) | — | |
| SCHEMBL6618 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5831095-A | Synthesis of 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imine | RESEARCH TRIANGLE INSTITUTE (US) | 1998-11-03 | — | — | US | claimed |
| EP-2648754-A2 | METHODS OF INHIBITING METASTASIS FROM CANCER | Philadelphia Health and Education Corporation D/B/A (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078633-A2 | METHODS OF INHIBITING METASTASIS FROM CANCER | PHILADELPHIA HEALTH AND EDUCATION CORPORATION, D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICENE (US) | 2012-06-14 | — | — | WO | disclosed |
| EP-1204640-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR | Millennium Pharmaceuticals, Inc. (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009094-A2 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-02-08 | — | — | WO | disclosed |
| EP-1049675-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR | Millennium Pharmaceuticals, Inc. (US) | 2000-11-08 | — | — | EP | disclosed |
| EP-1047675-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR | Millennium Pharmaceuticals, Inc. (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999037617-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 1999-07-29 | — | — | WO | disclosed |
| WO-1999037619-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 1999-07-29 | — | — | WO | disclosed |
| CN-1204258-A | Novel method | NOVO NORDISK AS (DK) | 1999-01-06 | — | — | CN | disclosed |
| US-5831095-A | Synthesis of 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imine | RESEARCH TRIANGLE INSTITUTE (US) | 1998-11-03 | — | — | US | disclosed |
| US-5795888-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 1998-08-18 | — | — | US | disclosed |
| US-5767120-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; TREATMENT FOR SEPTIC SHOCK | SCHERING CORPORATION (US) | 1998-06-16 | — | — | US | disclosed |
| US-5741791-A | ADMINISTERING COMPOUNDS WHICH INHIBIT SECRETION, CIRCULATION OR EFFECT OF INSULIN ANTAGONIZING PEPTIDES; CAN BE USED TO TREAT NON-INSULIN-DEPENDENT DIABETES MELLITUS | NOVO NORDISK A/S (DK) | 1998-04-21 | — | — | US | disclosed |
| US-5721254-A | ANTIINFLAMMATORY AGENTS; ANALGESICS | NOVO NORDISK A/S (DK) | 1998-02-24 | — | — | US | disclosed |
| US-5712292-A | N-substituted azaheterocyclic carboxylic acids and esters thereof | NOVO NORDISK A/S (DK) | 1998-01-27 | — | — | US | disclosed |
| US-5693649-A | ADMINISTERING TO TREAT NEUROGENIC INFLAMMATION, MIGRAINE OR DIABETIC NEUROPATHY | NOVO NORDISK A/S (DK) | 1997-12-02 | — | — | US | disclosed |
| US-5688788-A | ANTIINFLAMMATORY, ANALGESIC | NOVO NORDISK A/S (DK) | 1997-11-18 | — | — | US | disclosed |