SCHEMBL7516474

SCHEMBL7516474

COC(=O)C(=COCF)c1ccccc1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.47
TSHR P16473 1/20 0.47
NPC1 O15118 2/20 0.40
ATM Q13315 1/20 0.40
SMN1; SMN2 Q16637 5/20 0.40
KDM4E B2RXH2 4/20 0.40
TDP1 Q9NUW8 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
GAA P10253 4/20 0.38
KMT2A Q03164 4/20 0.38
MEN1 O00255 3/20 0.38
MAPT P10636 3/20 0.38
ALDH1A1 P00352 3/20 0.38
HIF1A Q16665 2/20 0.38
MPO P05164 1/20 0.38
EGFR P00533 1/20 0.37
NOX4 Q9NPH5 1/20 0.37
HPGD P15428 4/20 0.37
CYP2C19 P33261 2/20 0.37
HTT P42858 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7698025 1.00 LMNA (0.47) LMNATSHRNPC1ATMSMN1; SMN2
SCHEMBL7697415 0.86 MEN1 (0.44) LMNATSHRNPC1SMN1; SMN2KDM4E
SCHEMBL7697414 0.86 MEN1 (0.44) LMNATSHRNPC1SMN1; SMN2KDM4E
SCHEMBL8649869 0.85 HPGD (0.41) LMNANPC1SMN1; SMN2KDM4ETDP1
SCHEMBL8649867 0.85 HPGD (0.41) LMNANPC1SMN1; SMN2KDM4ETDP1
SCHEMBL1223756 0.83 LMNA (0.55) LMNATSHRNPC1ATMSMN1; SMN2
SCHEMBL1223761 0.83 LMNA (0.55) LMNATSHRNPC1ATMSMN1; SMN2
SCHEMBL710656 0.83 LMNA (0.55) LMNATSHRNPC1ATMSMN1; SMN2
SCHEMBL29721816 0.83 LMNA (0.55) LMNATSHRNPC1ATMSMN1; SMN2
SCHEMBL8080116 0.82 LMNA (0.44) LMNATSHRNPC1ATMSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0863886-B1 FLUOROMETHOXYACRYLIC ACID DERIVATIVES AND THEIR USE AS PEST CONTROL AGENTS BAYER AG (DE) 2002-01-09 EP disclosed
US-6337401-B1 MULTISTAGE REACTION OF AROMATIC FORMIC ACID DERIVATIVE IN THE PRESENCE OF A BASIC CATALYST TO FORM ENOL AND REACTION WITH BROMOFLUOROMETHANE AND FLUOROCHLOROMETHANE BAYER AKTIENGESELLSCHAFT (DE) 2002-01-08 US disclosed
EP-1061066-A2 Fluoromethoxyacrylic acid derivatives, intermediates in the preparation of pest control agents BAYER AG (DE) 2000-12-20 EP disclosed
US-6031107-A Fluoromethoxyacrylic acid derivatives and their use as pest control agents BAYER AKTIENGESELLSCHAFT (DE) 2000-02-29 US disclosed
EP-0863886-A1 FLUOROMETHOXYACRYLIC ACID DERIVATIVES AND THEIR USE AS PEST CONTROL AGENTS BAYER AG (DE) 1998-09-16 EP disclosed
WO-1997014687-A1 FLUOROMETHOXYACRYLIC ACID DERIVATIVES AND THEIR USE AS PEST CONTROL AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1997-04-24 WO disclosed