Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108399 | 0.82 | EGFR (0.53) | EGFRNR2F2SMN1; SMN2HTTNPC1 | |
| SCHEMBL7513679 | 0.81 | APP (0.60) | POLBSMN1; SMN2RAB9AALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7511516 | 0.80 | APP (0.59) | POLBSMN1; SMN2RAB9AALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7522378 | 0.80 | APP (0.59) | POLBSMN1; SMN2RAB9AALDH1A1LMNA | |
| SCHEMBL7511027 | 0.80 | EGFR (0.57) | EGFRNR2F2SMN1; SMN2HTTNPC1 | |
| SCHEMBL28174587 | 0.77 | LTA4H (0.56) | HTTLTA4HKDRALDH1A1LMNA | |
| SCHEMBL27887765 | 0.77 | CCNC (0.43) | EGFRPOLBNR2F2HTTNPC1 | |
| SCHEMBL7517528 | 0.76 | AR (0.51) | EGFRSMN1; SMN2HTTALDH1A1LMNA | |
| SCHEMBL1445588 | 0.76 | PDE10A (0.66) | SMN1; SMN2HTTNPC1RAB9ALTA4H | |
| SCHEMBL3112115 | 0.75 | EGFR (1.00) | EGFRPOLBNR2F2SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | claimed |
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | disclosed |