Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108399 | 0.86 | EGFR (0.53) | EGFRHTTPDE4APDE4BPDE4C | |
| SCHEMBL8545576 | 0.84 | HTT (0.59) | EGFRHTTPDE4APDE4BPDE4C | |
| SCHEMBL7516533 | 0.80 | EGFR (0.60) | EGFRHTTLMNARAB9ASMN1; SMN2 | |
| SCHEMBL27887765 | 0.78 | CCNC (0.43) | EGFRHTTPDE4APDE4BPDE4C | |
| SCHEMBL7511726 | 0.77 | PDE4A (0.50) | EGFRHTTPDE4APDE4BPDE4C | |
| SCHEMBL28174588 | 0.75 | KMT2A (0.58) | LMNASMN1; SMN2KMT2AMAPK1MAPT | |
| SCHEMBL1446555 | 0.73 | LMNA (0.48) | EGFRLMNAMAPK1MAPTL3MBTL1 | |
| SCHEMBL9921507 | 0.73 | EGFR (1.00) | EGFRHTTLMNARAB9ASMN1; SMN2 | |
| SCHEMBL12603256 | 0.73 | AHR (0.50) | EGFRHTTLMNARAB9ASMN1; SMN2 | |
| SCHEMBL7513679 | 0.73 | APP (0.60) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | claimed |
| EP-0832073-B1 | QUINAZOLINES AND PHARMACEUTICAL COMPOSITIONS | SUGEN INC (US) | 2002-01-16 | — | — | EP | disclosed |