Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.65 |
| ▸ | PLCD1 | P51178 | 1/20 | 0.65 |
| ▸ | F2 | P00734 | 1/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.57 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.56 |
| ▸ | CNR1 | P21554 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | IDE | P14735 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18779801 | 0.89 | TDP1 (0.78) | TDP1PLCD1F2PRSS1PRSS2 | |
| SCHEMBL12675370 | 0.88 | TDP1 (0.67) | TDP1PLCD1F2PRSS1PRSS2 | |
| SCHEMBL13497919 | 0.88 | TDP1 (0.67) | TDP1PLCD1F2PRSS1PRSS2 | |
| SCHEMBL17039697 | 0.88 | F2 (0.71) | TDP1PLCD1F2PRSS1PRSS2 | |
| SCHEMBL8508187 | 0.87 | TDP1 (0.71) | TDP1PLCD1F2PRSS1PRSS2 | |
| SCHEMBL10308270 | 0.86 | TDP1 (0.74) | TDP1PLCD1F2PRSS1PRSS2 | |
| SCHEMBL10140277 | 0.86 | TDP1 (0.65) | TDP1PLCD1F2PRSS1PRSS2 | |
| SCHEMBL10140256 | 0.86 | TDP1 (0.65) | TDP1PLCD1F2PRSS1PRSS2 | |
| SCHEMBL8532651 | 0.86 | TDP1 (0.68) | TDP1PLCD1F2PRSS1PRSS2 | |
| SCHEMBL28477644 | 0.86 | TDP1 (0.68) | TDP1PLCD1F2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832292-B1 | DNA POLYMERASE EXTENSION ASSAY FOR INFLUENZA VIRUS ENDONUCLEASE | MERCK & CO INC (US) | 2002-01-30 | — | — | EP | disclosed |
| EP-0833945-B1 | DNA POLYMERASE EXTENSION ASSAY | MERCK & CO INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-6100028-A | DETECTING SITE-SPECIFIC RIBOZYME ACTIVITY IN SAMPLE BY MIXING SUBSTRATE, SAMPLE AND INHIBITOR TO GENERATE RNA PRODUCT, HYBRIDIZING TO DNA, ADDING RADIOLABELED NUCLEOTIDE, ADDING DNA POLYMERASE, FILTERING TO RETAIN POLYMERASE PRODUCT, MEASURING | MERCK & CO., INC. (US) | 2000-08-08 | — | — | US | disclosed |
| EP-0833945-A4 | DNA POLYMERASE EXTENSION ASSAY | MERCK & CO INC (US) | 1999-05-19 | — | — | EP | disclosed |
| EP-0833945-A1 | DNA POLYMERASE EXTENSION ASSAY | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| US-5660989-A | DNA polymerase extension assay for influenza virus endonuclease | MERCK & CO., INC. (US) | 1997-08-26 | — | — | US | disclosed |
| WO-1996040994-A1 | DNA POLYMERASE EXTENSION ASSAY | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |