Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374354 | 0.94 | KMT2A (0.33) | LMNAALDH1A1SMN1; SMN2GAAPKM | |
| SCHEMBL4532046 | 0.93 | KMT2A (0.37) | ALDH1A1SMN1; SMN2PSMB8PSMB5KMT2A | |
| SCHEMBL29666930 | 0.93 | KMT2A (0.37) | ALDH1A1SMN1; SMN2PSMB8PSMB5KMT2A | |
| Trifluoromethanesulfonic Acid SCHEMBL29698948 | 0.91 | PSMB8 (0.32) | LMNAALDH1A1SMN1; SMN2GAAPKM | |
| Trifluoromethanesulfonic Acid SCHEMBL12096566 | 0.91 | PSMB8 (0.32) | LMNAALDH1A1SMN1; SMN2GAAPKM | |
| Trifluoromethanesulfonic Acid SCHEMBL2225877 | 0.86 | PSMB8 (0.32) | LMNAALDH1A1SMN1; SMN2GAAPKM | |
| SCHEMBL9426644 | 0.84 | PSMB8 (0.32) | PSMB8PSMB5 | |
| Trifluoromethanesulfonic Acid SCHEMBL16227774 | 0.80 | PSMB8 (0.32) | LMNAALDH1A1SMN1; SMN2GAAPKM | |
| SCHEMBL31165787 | 0.79 | KMT2A (0.36) | LMNAALDH1A1SMN1; SMN2GAAPKM | |
| Trifluoromethanesulfonic Acid SCHEMBL4624488 | 0.78 | PSMB8 (0.34) | PSMB8PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647628-B1 | Acridinium derivatives and their use in luminescence immunoassays | DADE BEHRING MARBURG GMBH (DE) | 2002-09-11 | — | — | EP | disclosed |
| EP-0330050-B1 | Special chemiluminescent acridine derivatives and their use in luminescence immunoassays | DADE BEHRING MARBURG GMBH (DE) | 2000-08-23 | — | — | EP | disclosed |
| US-6002007-A | Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays | DADE BEHRING MARBURG GMBH (DE) | 1999-12-14 | — | — | US | disclosed |
| US-5879953-A | Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |
| US-5783696-A | Special chemiluminescent acridine derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-21 | — | — | US | disclosed |
| EP-0257541-B1 | Chemilumuniscent acridine derivatives and their use in luminescence immunoassays | HOECHST AG (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0647628-A1 | Acridmium derivatives and their use in luminescence immunoassays | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-12 | — | — | EP | disclosed |
| EP-0257541-A2 | Chemilumuniscent acridine derivatives and their use in luminescence immunoassays | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-03-02 | — | — | EP | disclosed |