Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 12/20 | 0.65 |
| ▸ | CAPNS1 | P04632 | 2/20 | 0.63 |
| ▸ | CTSK | P43235 | 6/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.42 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810052 | 0.91 | CAPN1 (0.66) | CAPN1CAPNS1CTSKCASP1CASP3 | |
| SCHEMBL8810074 | 0.91 | CAPN1 (0.66) | CAPN1CAPNS1CTSKCASP1CASP3 | |
| SCHEMBL8404221 | 0.90 | CAPN1 (0.65) | CAPN1CAPNS1CTSKCASP1CASP3 | |
| SCHEMBL8404224 | 0.90 | CAPN1 (0.65) | CAPN1CAPNS1CTSKCASP1CASP3 | |
| SCHEMBL7517291 | 0.84 | CAPN1 (0.58) | CAPN1CAPNS1CTSKCASP1CASP3 | |
| SCHEMBL7514483 | 0.83 | CAPN1 (0.49) | CAPN1CAPNS1CTSK | |
| SCHEMBL8808955 | 0.82 | CAPN1 (0.62) | CAPN1CAPNS1CASP1 | |
| SCHEMBL8808938 | 0.82 | CAPN1 (0.62) | CAPN1CAPNS1CASP1 | |
| SCHEMBL7514155 | 0.81 | CAPN1 (0.59) | CAPN1CAPNS1CTSK | |
| SCHEMBL27428996 | 0.81 | CAPN1 (0.59) | CAPN1CAPNS1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0641800-A1 | Lactol derivatives as inhibiters of cathepsin L | Takeda Chemical Industries, Ltd. (JP) | 1995-03-08 | — | — | EP | disclosed |