SCHEMBL8404221

SCHEMBL8404221

CC(=O)O[C@@H]1OCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)c1ccc(Cl)cc1

nearest known ligand 0.65

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CAPN1 P07384 12/20 0.65
CAPNS1 P04632 2/20 0.63
CTSK P43235 6/20 0.46
CCR1 P32246 1/20 0.46
CASP1 P29466 1/20 0.44
CASP3 P42574 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8404224 1.00 CAPN1 (0.65) CAPN1CAPNS1CTSKCCR1CASP1
SCHEMBL8810074 0.91 CAPN1 (0.66) CAPN1CAPNS1CTSKCASP1CASP3
SCHEMBL8810052 0.91 CAPN1 (0.66) CAPN1CAPNS1CTSKCASP1CASP3
SCHEMBL7517376 0.90 CAPN1 (0.65) CAPN1CAPNS1CTSKCASP1CASP3
SCHEMBL8404257 0.85 CAPN1 (0.62) CAPN1CAPNS1CTSKCCR1CASP1
SCHEMBL8404253 0.85 CAPN1 (0.62) CAPN1CAPNS1CTSKCCR1CASP1
SCHEMBL7517291 0.84 CAPN1 (0.58) CAPN1CAPNS1CTSKCASP1CASP3
SCHEMBL8404222 0.83 CAPN1 (0.47) CAPN1CAPNS1CCR1
SCHEMBL8406511 0.83 CAPN1 (0.49) CAPN1CAPNS1CTSK
SCHEMBL8406503 0.83 CAPN1 (0.49) CAPN1CAPNS1CTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0925786-A1 REMEDIES FOR ISCHEMIC DISEASES MITSUBISHI CHEMICAL CORPORATION (JP) 1999-06-30 EP disclosed
EP-0810221-A1 OXYGEN-CONTAINING HETEROCYCLIC DERIVATIVES MITSUBISHI CHEMICAL CORPORATION (JP) 1997-12-03 EP disclosed