Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | G6PD | P11413 | 2/20 | 0.67 |
| ▸ | PKM | P14618 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | MPI | P34949 | 1/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.63 |
| ▸ | STS | P08842 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | DAB2IP | Q5VWQ8 | 1/20 | 0.55 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6263461 | 1.00 | ESR1 (0.67) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL7924361 | 1.00 | ESR1 (0.67) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL7624080 | 0.88 | ESR1 (0.53) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL10079009 | 0.88 | ESR1 (0.51) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL15307736 | 0.85 | ESR1 (0.48) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL11782064 | 0.85 | HSD17B10 (0.54) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL3402210 | 0.81 | ESR1 (0.68) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL11100047 | 0.81 | CYP19A1 (0.62) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL5526013 | 0.81 | ESR1 (0.82) | ESR1ESR2LMNAMEN1MAPT | |
| SCHEMBL5526011 | 0.81 | ESR1 (0.82) | ESR1ESR2LMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020065258-A1 | Non-estrogenic estradiol derivative compounds with antioxidative activity | DROESCHER PETER (DE) | 2002-05-30 | — | — | US | claimed |
| EP-0986573-B1 | NON-ESTROGENIC ESTRADIOL DERIVATIVES WITH AN ANTIOXIDANT EFFECT | JENAPHARM GMBH (DE) | 2002-10-09 | — | — | EP | disclosed |
| US-6436917-B1 | Non-estrogenic estradiol derivative compounds with anti-oxidative activity | JENAPHARM GMBH & CO. KG (DE) | 2002-08-20 | — | — | US | disclosed |
| US-20020065258-A1 | Non-estrogenic estradiol derivative compounds with antioxidative activity | DROESCHER PETER (DE) | 2002-05-30 | — | — | US | disclosed |
| US-3956348-A | Steroid ether splitting | SCHERING AKTIENGESELLSCHAFT (DT) | 1976-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065258-A1 | Non-estrogenic estradiol derivative compounds with antioxidative activity | CYP19A1, HSD17B11, SULT2A1 | ESR1 7/4885ESR2 6/4885LMNA 4643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.