Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 4/20 | 0.52 |
| ▸ | NAMPT | P43490 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614650 | 0.84 | KMT2A (0.58) | TP53CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8816782 | 0.83 | CHRNB2 (0.54) | CHRNB2CHRNB4CHRNA3CHRNA4PPARG | |
| SCHEMBL7407228 | 0.81 | NPC1 (0.60) | NPC1RAB9ATP53CHRNB2CHRNB4 | |
| SCHEMBL6793810 | 0.80 | KDR (0.52) | NPC1RAB9ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7612253 | 0.79 | RXFP1 (0.54) | TP53PPARGNAMPTALDH1A1HPGD | |
| SCHEMBL15555884 | 0.79 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4PPARG | |
| SCHEMBL6794304 | 0.79 | GRM4 (0.55) | CHRNB2CHRNB4CHRNA3CHRNA4PPARG | |
| SCHEMBL8816842 | 0.78 | KMT2A (0.52) | TP53CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7517678 | 0.77 | NPC1 (0.47) | NPC1RAB9ATP53CHRNB2CHRNB4 | |
| SCHEMBL25872270 | 0.77 | MEN1 (0.72) | NPC1RAB9ATP53PPARGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |