Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPN | P05981 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SQLE | Q14534 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6054922 | 0.87 | CA2 (0.45) | CA2CA1PTGS1PTGS2MAPT | |
| SCHEMBL7521161 | 0.87 | ALDH1A1 (0.42) | MAPTALOX15GAAALDH1A1POLB | |
| Dimethylamine SCHEMBL7513266 | 0.86 | CA2 (0.41) | CA2CA1MAPTHPNALOX15 | |
| SCHEMBL8385616 | 0.86 | CA2 (0.44) | CA2CA1PTGS1PTGS2MAPT | |
| SCHEMBL6054877 | 0.86 | CA1 (0.39) | CA2CA1MAPTALOX15GAA | |
| SCHEMBL8389818 | 0.85 | PTGS1 (0.46) | CA2CA1PTGS1PTGS2MAPT | |
| SCHEMBL8387081 | 0.85 | CA2 (0.42) | CA2CA1PTGS1PTGS2MAPT | |
| SCHEMBL8038870 | 0.85 | CA2 (0.54) | CA2CA1PTGS1PTGS2MAPT | |
| SCHEMBL5692389 | 0.85 | CA2 (0.45) | CA2CA1PTGS1PTGS2MAPT | |
| SCHEMBL7515902 | 0.84 | CA2 (0.41) | CA2CA1PTGS1PTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |