⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1396342 | 1.00 | — | — | |
| SCHEMBL751802 | 1.00 | — | — | |
| Acrylamide SCHEMBL8399794 | 0.84 | ALDH1A1 (0.55) | — | |
| SCHEMBL20237254 | 0.79 | — | — | |
| SCHEMBL1704654 | 0.79 | — | — | |
| Oxamate SCHEMBL5533236 | 0.77 | LDHA (0.75) | — | |
| SCHEMBL105998 | 0.76 | FFAR3 (0.55) | — | |
| SCHEMBL141678 | 0.76 | FFAR3 (0.55) | — | |
| SCHEMBL10661655 | 0.76 | FFAR3 (0.55) | — | |
| SCHEMBL10661623 | 0.76 | FFAR3 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 192 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114381932-A | Light anti-static fabric and preparation method thereof | 盐城市美斯特制衣有限公司 | 2022-04-22 | — | — | CN | claimed |
| CN-108152411-B | Method for detecting impurities in 3-amino-2-methyl crotonate | 湖南新领航检测技术有限公司 | 2020-07-07 | — | — | CN | claimed |
| EP-3168215-B1 | PROCESS FOR PREPARATION OF BARNIDIPINE | USV PRIVATE LTD (IN) | 2020-05-20 | — | — | EP | claimed |
| EP-3168215-A2 | PROCESS FOR PREPARATION OF BARNIDIPINE | USV Private Limited (IN) | 2017-05-17 | — | — | EP | claimed |
| EP-2386544-B1 | Preparation of dihydropyridines | LESVI LABORATORIOS SL (ES) | 2016-02-10 | — | — | EP | claimed |
| EP-1940790-B1 | POLYMORPHIC FORM OF LERCANIDIPINE HYDROCHLORIDE AND PROCESS FOR THE PREPARATION THEREOF | GLENMARK PHARMACEUTICALS LTD (IN) | 2015-09-02 | — | — | EP | claimed |
| US-20130131126-A1 | DERIVATIVES OF 1,4-DIHYDROPYRIDINE POSSESSING ANTIVIRAL EFFICACY | JSC GRINDEKS (LV) | 2013-05-23 | — | — | US | claimed |
| US-7585978-B2 | Processes of manufacturing substituted-1,4-dihydropyridines, improved aqueous solutions thereof, and processes of manufacturing the solutions | NAVINTA LLC (US) | 2009-09-08 | — | — | US | claimed |
| EP-1532110-B1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE SPA (IT) | 2008-07-23 | — | — | EP | claimed |
| US-20080125595-A1 | Single step one pot process for making nicardipine hydrochloride from 3-nitro-benzaldehyde, methyl aminocrotonate, and N-benzyl-N-methylaminoethyl acetoacetate; aqueous, injectable isotonic solution of nicardipine hydrochloride, L-arginine, and a sugar alcohol | NAVINTA LLC. | 2008-05-29 | — | — | US | claimed |
| EP-0902016-B1 | A process and intermediate compounds for the preparation of amlodipine benzene sulphonate | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2002-05-02 | — | — | EP | claimed |
| US-6306203-B1 | FOR USE IN INK JET PRINTING, INCLUDING PIEZOELECTRIC INK JET PRINTING AND ACOUSTIC INK JET PRINTING | XEROX CORPORATION | 2001-10-23 | — | — | US | claimed |
| US-6046337-A | Process for the preparation of a dihydropyridine derivative | EGIS GYOGYSZERGYAR RT. (HU) | 2000-04-04 | — | — | US | claimed |
| EP-0902016-A1 | A process and intermediate compounds for the preparation of amlodipine benzene sulphonate | EGIS GYOGYSZERGYAR (HU) | 1999-03-17 | — | — | EP | claimed |
| EP-0902016-A2 | A process and intermediate compounds for the preparation of amlodipine benzene sulphonate | EGIS GYOGYSZERGYAR RT. (HU) | 1999-03-17 | — | — | EP | claimed |
| EP-0326389-B1 | Process for preparing 4-hydroxypyrimidine | UBE INDUSTRIES (JP) | 1996-09-11 | — | — | EP | claimed |
| EP-0226558-B1 | Chemical intermediates and methods for their preparation | HAESSLE AB (SE) | 1994-04-06 | — | — | EP | claimed |
| US-5126457-A | Reacting nitrophenyl imines or diimines with methyl acetoacetate and amino or ammonium compounds yields high purity Nifedipine | EGIS GYOGYSZERGYAR (HU) | 1992-06-30 | — | — | US | claimed |
| EP-0379351-A1 | 1,4-Dihydropyridine derivatives | SYNPHAR LABORATORIES INC. (CA) | 1990-07-25 | — | — | EP | claimed |
| US-4042646-A | BETA-AMINO-ALPHA, BETA-UNSATURATED KETONE, POLYESTERS | NIHON YUSHI CO., LTD. (JA) | 1977-08-16 | — | — | US | claimed |