Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.49 |
| ▸ | CHUK | O15111 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | DKK1 | O94907 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12275887 | 0.79 | IKBKB (0.60) | IKBKBMEN1KMT2ABRD4NPC1 | |
| SCHEMBL1667472 | 0.79 | MEN1 (0.75) | IKBKBMEN1KMT2ABRD4NPC1 | |
| SCHEMBL6033236 | 0.78 | KDR (0.67) | RAB9A | |
| SCHEMBL12274400 | 0.77 | AIMP2 (0.61) | MEN1KMT2ABRD4NPC1RAB9A | |
| SCHEMBL12274387 | 0.75 | SMG1 (0.60) | SMG1 | |
| SCHEMBL1667082 | 0.74 | SYK (0.60) | IKBKBCHUKMEN1KMT2ABRD4 | |
| SCHEMBL7518599 | 0.74 | CDK1 (0.43) | MEN1KMT2A | |
| SCHEMBL1667086 | 0.73 | PLK1 (0.68) | IKBKBCHUKMEN1KMT2ABRD4 | |
| SCHEMBL12275241 | 0.73 | PLK1 (0.61) | IKBKBCHUKMEN1KMT2ABRD4 | |
| SCHEMBL12274499 | 0.73 | PLK1 (0.73) | IKBKBMEN1KMT2ABRD4SMG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020147339-A1 | 5-cyano-2-aminopyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2002-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147339-A1 | 5-cyano-2-aminopyrimidine derivatives | FLT1, FGFR1, KDR | IKBKB 1417/4885CHUK 145/4885MEN1 4769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.