Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.77 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | FABP4 | P15090 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6387684 | 0.90 | F10 (0.83) | F10MAPTPKMPOLBKDM4E | |
| SCHEMBL29123955 | 0.88 | MAPT (0.72) | F10MAPTPKMPOLBKDM4E | |
| SCHEMBL7516738 | 0.87 | MAPT (0.62) | F10MAPTPKMPOLBKDM4E | |
| SCHEMBL11189465 | 0.87 | PKM (0.68) | F10MAPTPKMPOLBKDM4E | |
| SCHEMBL11186378 | 0.86 | MAPT (0.67) | F10MAPTPKMPOLBKDM4E | |
| SCHEMBL6391914 | 0.84 | MAPT (0.64) | F10MAPTPKMPOLBKDM4E | |
| SCHEMBL6386373 | 0.80 | F10 (0.65) | F10MAPTPRSS1PRSS2PRSS3 | |
| SCHEMBL6568071 | 0.80 | F10 (0.64) | F10MAPTPOLBPRSS1PRSS2 | |
| SCHEMBL6428782 | 0.80 | MAPT (0.56) | F10MAPTPKMPOLBKDM4E | |
| SCHEMBL13543514 | 0.80 | MAPT (0.79) | MAPTPKMPOLBKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1174421-A1 | 3-AMIDINOBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES IN THE PRODUCTION THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2002-01-23 | — | — | EP | disclosed |