Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.39 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7064404 | 0.97 | TSHR (0.48) | TSHRCYP1A2LMNACYP2A6IDO1 | |
| Iodide SCHEMBL7517751 | 0.95 | TSHR (0.50) | TSHRCYP1A2LMNACYP2A6IDO1 | |
| Hydrochloric Acid SCHEMBL7063181 | 0.95 | TSHR (0.50) | TSHRCYP1A2LMNACYP2A6IDO1 | |
| Bromide SCHEMBL7874765 | 0.89 | LMNA (0.53) | TSHRCYP1A2LMNACYP2A6IDO1 | |
| SCHEMBL11324654 | 0.88 | TSHR (0.43) | TSHRCYP1A2LMNACYP2A6IDO1 | |
| SCHEMBL10884086 | 0.88 | TSHR (0.43) | TSHRCYP1A2LMNACYP2A6IDO1 | |
| SCHEMBL7060292 | 0.88 | CYP1A2 (0.48) | TSHRCYP1A2LMNACYP2A6IDO1 | |
| SCHEMBL10884076 | 0.84 | TSHR (0.40) | TSHRCYP1A2LMNACYP2A6IDO1 | |
| SCHEMBL7060290 | 0.84 | TSHR (0.40) | TSHRCYP1A2LMNACYP2A6IDO1 | |
| Iodide SCHEMBL7901726 | 0.83 | LMNA (0.53) | TSHRCYP1A2LMNACYP2A6IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174918-B2 | Process for preparing diaryl oxalate | UBE INDUSTRIES, LTD. (JP) | 2015-11-03 | — | — | US | disclosed |
| US-20120296063-A1 | PROCESS FOR PREPARING DIARYL OXALATE | UBE CORPORATION (JP) | 2012-11-22 | — | — | US | disclosed |
| EP-0832910-B1 | Process for producing a polycarbonate | UBE INDUSTRIES (JP) | 2002-06-26 | — | — | EP | disclosed |
| EP-0832872-B1 | Process for producing diaryl carbonate | UBE INDUSTRIES (JP) | 2002-01-30 | — | — | EP | disclosed |
| EP-0834496-B1 | Preparation of diaryl carbonate | UBE INDUSTRIES (JP) | 2001-08-16 | — | — | EP | disclosed |
| US-6169209-B1 | BRINGING AN ORGANIC PHOSPHONIUM BROMIDE INTO CONTACT WITH A CHLORIDE ION IN A HETEROGENEOUS MIXTURE SOLUTION COMPRISING WATER AND AN ORGANIC SOLVENT TO FORM ORGANIC PHOSPHONIUM CHLORIDE | UBE INDUSTRIES, LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0834495-B1 | Process for preparing diaryl carbonate | UBE INDUSTRIES (JP) | 2000-12-27 | — | — | EP | disclosed |
| US-5922827-A | Process for producing a polycarbonate | UBE INDUSTRIES, LTD. (JP) | 1999-07-13 | — | — | US | disclosed |
| US-5892089-A | FROM DIARYL OXALATE IN LIQUID PHASE BY DECARBONYLATION USING ORGANIC PHOSHORUS COMPOUND CATALYST | UBE INDUSTRIES, LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| US-5892091-A | PHOSPHOROUS CATALYSTS AND HALOGEN ATOMS | UBE INDUSTRIES, LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0834496-A1 | Preparation of diaryl carbonate | UBE INDUSTRIES, LTD. (JP) | 1998-04-08 | — | — | EP | disclosed |
| EP-0832910-A2 | Process for producing a polycarbonate | UBE INDUSTRIES, LTD. (JP) | 1998-04-01 | — | — | EP | disclosed |
| EP-0832872-A1 | Process for producing diaryl carbonate | UBE INDUSTRIES, LTD. (JP) | 1998-04-01 | — | — | EP | disclosed |
| EP-0826658-A1 | Catalyst for decarbonylation reaction | UBE INDUSTRIES, LTD. (JP) | 1998-03-04 | — | — | EP | disclosed |
| US-5648510-A | DECARBONYLATION OF OXALATE | UBE INDUSTRIES, LTD. (JP) | 1997-07-15 | — | — | US | disclosed |
| EP-0737665-A1 | Process for preparation of diaryl carbonate | UBE INDUSTRIES, LTD. (JP) | 1996-10-16 | — | — | EP | disclosed |
| EP-0220810-B1 | INSECTICIDAL ETHERS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-05-02 | — | — | EP | disclosed |
| US-4788348-A | HYDROXY AROMATIC ETHERS AS CHEMICAL INTERMEDIATES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-11-29 | — | — | US | disclosed |
| US-4705900-A | Insecticidal alkenes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-11-10 | — | — | US | disclosed |
| EP-0220810-A1 | Insecticidal ethers | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-05-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120296063-A1 | PROCESS FOR PREPARING DIARYL OXALATE | TH, CYP2E1, ADH1A | TSHR 1038/4885CYP1A2 13/4885LMNA 3146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.