Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | ITGAL | P20701 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10148115 | 0.84 | MTNR1A (0.54) | MTNR1ADAOROCK2CYP3A4CYP2D6 | |
| SCHEMBL5018846 | 0.78 | MTNR1A (0.48) | MTNR1ADAOROCK2CYP3A4CYP2D6 | |
| SCHEMBL2260662 | 0.76 | MTNR1A (0.49) | MTNR1ADAOROCK2CYP3A4CYP2D6 | |
| SCHEMBL7519080 | 0.74 | MTNR1A (0.53) | MTNR1ADAOROCK2CYP3A4CYP2D6 | |
| SCHEMBL10148114 | 0.74 | GABRA1 (0.47) | MTNR1ACYP2D6KDM4E | |
| SCHEMBL1253283 | 0.74 | MTNR1A (0.67) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2023947 | 0.73 | MTNR1A (0.53) | MTNR1ADAOROCK2CYP3A4CYP2D6 | |
| SCHEMBL8736674 | 0.73 | MTNR1A (0.61) | MTNR1ADAOROCK2CYP3A4CYP2D6 | |
| SCHEMBL8763083 | 0.72 | CYP1A1 (0.38) | CYP3A4CYP2D6MAOAMAOB | |
| SCHEMBL7268290 | 0.72 | MTNR1A (0.56) | MTNR1ADAOROCK2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | disclosed |
| US-5919814-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | disclosed |