SCHEMBL7519352

SCHEMBL7519352

CCCc1cnc(-c2ccc(F)c(F)c2)nc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.51
SMN1; SMN2 Q16637 5/20 0.51
NPC1 O15118 4/20 0.51
HSD17B10 Q99714 3/20 0.51
TP53 P04637 2/20 0.51
PKM P14618 1/20 0.51
RARB P10826 1/20 0.42
PDGFRB P09619 1/20 0.39
PDGFRA P16234 1/20 0.39
CYP11B1 P15538 2/20 0.39
CYP11B2 P19099 2/20 0.39
CYP17A1 P05093 1/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
ALDH1A1 P00352 2/20 0.39
GAA P10253 2/20 0.39
KDM4E B2RXH2 1/20 0.39
USP2 O75604 1/20 0.39
MAPT P10636 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9149216 0.94 RAB9A (0.49) RAB9ASMN1; SMN2NPC1HSD17B10TP53
SCHEMBL10728895 0.90 RARB (0.50) RAB9ASMN1; SMN2NPC1HSD17B10TP53
SCHEMBL7516234 0.89 RARB (0.56) RAB9ASMN1; SMN2NPC1HSD17B10TP53
SCHEMBL10733402 0.88 RARB (0.58) RAB9ASMN1; SMN2NPC1HSD17B10TP53
SCHEMBL10731135 0.88 RARB (0.58) RAB9ASMN1; SMN2NPC1HSD17B10TP53
SCHEMBL10719819 0.86 GRIN2B (0.43) RAB9ASMN1; SMN2NPC1HSD17B10TP53
SCHEMBL9029824 0.86 RAB9A (0.45) RAB9ASMN1; SMN2NPC1HSD17B10TP53
SCHEMBL14749466 0.84 RAB9A (0.44) RAB9ASMN1; SMN2NPC1HSD17B10TP53
SCHEMBL9763621 0.84 RAB9A (0.46) RAB9ASMN1; SMN2NPC1HSD17B10TP53
SCHEMBL13788506 0.83 RAB9A (0.43) RAB9ASMN1; SMN2NPC1HSD17B10TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4640795-A REDUCED OPERATING VOLTAGE CHISSO CORPORATION (JP) 1987-02-03 US claimed
CN-112675850-A Nickel catalyst, preparation method thereof and synthesis method of pyrimidine derivatives 江苏广域化学有限公司 2021-04-20 CN disclosed
US-7198827-B1 Nematic liquid crystal composition and liquid crystal display device using the same DAINIPPON INK AND CHEMICALS, INC. (JP) 2007-04-03 US disclosed
US-7198827-B1 Nematic liquid crystal composition and liquid crystal display device using the same DAINIPPON INK AND CHEMICALS, INC. (JP) 2007-04-03 US disclosed
EP-0742275-B1 LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME CHISSO CORP (JP) 2002-03-20 EP disclosed
EP-0640578-B2 Novel liquid crystalline compound having a 1,1,2,3,3,3,-hexafluoropropyl group and liquid crystal composition CHISSO CORP (JP) 2001-06-27 EP disclosed
US-6143198-A SUITABLE FOR USE AS ELECTRO-OPTICAL DISPLAY MATERIALS; LIQUID CRYSTALLINE COMPOUND HAVING A LARGE ELASTIC CONSTANT RATIO, EXCELLENT COMPATIBILITY WITH OTHER LIQUID CRYSTALLINE COMPOUND, AND LOW TEMPERATURE CHEMICAL STABILITY CHISSO CORPORATION (JP) 2000-11-07 US disclosed
EP-0805134-B1 NOVEL LIQUID-CRYSTAL COMPOUNDS BEARING DIENYL MOIETY AND LIQUID-CRYSTAL COMPOSITION CHISSO CORP (JP) 2000-08-30 EP disclosed
EP-0728829-B1 Liquid crystalline alkenylcyclohexene derivative, liquid crystal composition and liquid crystal display element CHISSO CORP (JP) 2000-05-03 EP disclosed
EP-0700982-B1 A liquid crystal composition and a liquid crystal display element using the same CHISSO CORP (JP) 2000-04-26 EP disclosed
US-5344587-A Nitriles MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1994-09-06 US disclosed
EP-0316186-B1 Liquid crystal compositions CHISSO CORP (JP) 1994-08-17 EP disclosed
EP-0597701-A1 Conjugated enyne derivative and liquid crystal composition CHISSO CORPORATION (JP) 1994-05-18 EP disclosed
EP-0318003-B1 A liquid crystal composition for twist nematic mode CHISSO CORP (JP) 1993-10-20 EP disclosed
EP-0452460-A1 ELECTRO-OPTICAL LIQUID CRYSTAL SYSTEM. MERCK PATENT GMBH (DE) 1991-10-23 EP disclosed
US-5021189-A Supertwisted birefringence display CHISSO CORPORATION (JP) 1991-06-04 US disclosed
WO-1991005029-A1 ELECTRO-OPTICAL LIQUID CRYSTAL SYSTEM MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1991-04-18 WO disclosed
EP-0318003-A2 A liquid crystal composition for twist nematic mode CHISSO CORPORATION (JP) 1989-05-31 EP disclosed
EP-0316186-A2 Liquid crystal compositions Chisso Corporation (JP) 1989-05-17 EP disclosed
US-4640795-A REDUCED OPERATING VOLTAGE CHISSO CORPORATION (JP) 1987-02-03 US disclosed